1. In an Inline Table Valued function, the RETURNS clause cannot contain the structure of the table, the function returns. Where as, with the multi-statement table valued function, we specify the structure of the table that gets returned
2. Inline Table Valued function cannot have BEGIN and END block, where as the multi-statement function can have.
3. Inline Table valued functions are better for performance, than multi-statement table valued functions. If the given task, can be achieved using an inline table valued function, always prefer to use them, over multi-statement table valued functions.
4. It's possible to update the underlying table, using an inline table valued function, but not possible using multi-statement table valued function.

 Ref: http://csharp-video-tutorials.blogspot.com/2012/09/multi-statement-table-valued-functions.html